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pentobarbital will lessen the extent or result of verapamil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/check. pentobarbital will decrease the extent or influence of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/watch. pentobarbital decreases levels of elvitegravir/cobicistat/emtricita